Arrhythmias and sudden death panel

Arrhythmias and Sudden Death without Structural Cardiopathy General Panel
[90 genes]

It includes priority genes with a clear association with these diseases, secondary genes where the evidence is lower, and candidate genes gathered from a systematic literature review

Study requisition form
Informed consent
CACNA1C CALM1 CALM2 CALM3 CASQ2 DES DSC2 DSG2 DSP EMD
FLNC JUP KCNE1 KCNE2 KCNH2 KCNJ2 KCNQ1 LMNA MYH7 NKX2-5
PKP2 PLN PRKAG2 RYR2 SCN5A TNNC1 TNNI3 TNNT2 ACTC1 AKAP9
ANK2 CACNA1D CACNA2D1 CACNB2 CAV3 FHL2 GAA GJA5 GLA GNB2
GPD1L HCN4 IRX3 KCNA5 KCND3 KCNE3 KCNE5 KCNJ5 KCNJ8 LAMP2
MYH6 PITX2 SCN1B SCN2B SCN4B SLC22A5 SNTA1 TBX5 TECRL TMEM43
TNNI3K TRDN TRPM4 TTR ABCC9* ANK3* CAVIN1* CAVIN4* CDH2* FGF12*
GATA5* GJA1* GREM2* KCND2* KCNK17* KCNK3* LDB3* MYBPHL* NKX2-6* NOS1AP*
NPPA* PPA2* RANGRF* SCN10A* SCN3B* SLMAP* SYNE2* TMEM175* TPM1* ZFHX3*
Arrhythmias and Sudden Death without Structural Cardiopathy General Panel [90 genes]

It includes priority genes with a clear association with these diseases, secondary genes where the evidence is lower, and candidate genes gathered from a systematic literature review.

Study requisition form
Informed consent
CACNA1C CALM1 CALM2 CALM3
CASQ2 DES DSC2 DSG2
DSP EMD FLNC JUP
KCNE1 KCNE2 KCNH2 KCNJ2
KCNQ1 LMNA MYH7 NKX2-5
PKP2 PLN PRKAG2 RYR2
SCN5A TNNC1 TNNI3 TNNT2
ACTC1 AKAP9 ANK2 CACNA1D
CACNA2D1 CACNB2 CAV3 FHL2
GAA GJA5 GLA GNB2
GPD1L HCN4 IRX3 KCNA5
KCND3 KCNE3 KCNE5 KCNJ5
KCNJ8 LAMP2 MYH6 PITX2
SCN1B SCN2B SCN4B SLC22A5
SNTA1 TBX5 TECRL TMEM43
TNNI3K TRDN TRPM4 TTR
ABCC9* ANK3* CAVIN1* CAVIN4*
CDH2* FGF12* GATA5* GJA1*
GREM2* KCND2* KCNK17* KCNK3*
LDB3* MYBPHL* NKX2-6* NOS1AP*
NPPA* PPA2* RANGRF* SCN10A*
SCN3B* SLMAP* SYNE2* TMEM175*
TPM1* ZFHX3*
Nota genes
NOTES ON GENES
-> Priority genes: Genes where there is sufficient evidence (clinical and functional) to consider them as associated with the disease; they are included in clinical practice guidelines. -> Secondary genes: Genes related to the disease but with a lower level of evidence
or constituting sporadic cases. -> * Candidate genes: Without sufficient evidence in humans but potentially associated with the disease.

It includes diseases that can cause ventricular arrhythmias and sudden death as their first clinical manifestation. Therefore, channelopathies and some genes associated with cardiomyopathies but capable of producing ventricular arrhythmias without any apparent cardiac involvement are included.

  • This panel is mainly oriented at diagnosing of phenotypes that present ventricular arrhythmias as a primary manifestation of the disease without apparent structural heart disease and not clearly defined phenotype.
  • It is intended for those individuals whose clinical or anatomopathological study does not show structural alterations, and would be the testing of choice in cases of sudden death with negative autopsy.
  • It should be especially considered in patients with personal or family history of sudden death, subjects with a history of syncope of undetermined origin, or individuals with idiopathic ventricular fibrillation without structural heart disease.
Cookies settings
When you visit our website, it may store information through your browser from specific services, usually in the form of cookies. It is worth noting that blocking somo types of cookies may impact your experience on our website.