Arrhythmias Global Panel

Arrhythmias and Sudden Death Global Panel
[251 genes]

It includes priority genes with a clear association with these diseases, secondary genes where the evidence is lower, and candidate genes gathered from a systematic literature review.

Study requisition form
Informed consent
ACTC1BAG3CACNA1CCALM1CALM2CALM3CASQ2DESDMDDSC2
DSG2DSPEMDFHL1FHOD3FLNCGLAJUPKCNE1KCNE2
KCNH2KCNJ2KCNQ1LAMP2LMNAMYBPC3MYH7MYL2MYL3NKX2-5
PKP2PLNPRKAG2PTPN11RBM20RYR2SCN5ATNNC1TNNI3TNNT2
TPM1TRIM63TTNTTRAARS2ACAD9ACADVLACTA1ACTN2AGK
AGLAGPAT2AKAP9ALMS1ALPK3ANK2ANO5ATPAF2CACNA1DCACNA2D1
CACNB2CAV3COA5COA6COQ2COX15COX6B1CRYABCSRP3CTNNA3
DLDDNAJC19DOLKDTNAEYA4FAHFHL2FKRPFKTNFOXRED1
GAAGATA4GATA5GATA6GFM1GJA5GLB1GNB2GNPTABGUSB
GYG1HCN4HFEHRASIRX3JPH2KCND3KCNE3KCNE5KCNJ5
KCNJ8KLHL24KRASLAMA2LDLRLIASLZTR1MAP2K1MAP2K2MLYCD
MRPL3MRPL44MRPS22MTO1MYBPHLMYOTMYOZ2MYPNNF1NRAS
PMM2PPA2PPCSPRDM16QRSL1RAF1RIT1SCN1BSCN2BSCO2
SDHASGCDSGCGSHOC2SLC22A5SLC25A3SNTA1SOS1SPEGSURF1
TAZTBX20TBX5TCAPTECRLTMEM43TMEM70TNNI3KTRDNTRPM4
ZBTB17A2ML1*ABCC9*AKT1*ANK3*ANKRD1*ATP5F1E*BRAF*BSCL2*C10orf71*
CALR*CALR3*CASZ1*CAVIN1*CAVIN4*CBL*CDH2*CHRM2*COL7A1*CTNNA1*
CTNNB1*DNM1L*ELAC2*FBXO32*FGF12*FXN*GATAD1*GJA1*GPD1L*GREM2*
GSK3B*IDH2*ILK*ISM2*JARID2*KAT6B*KCNA5*KCND2*KCNK17*KLF10*
LAMA4*LDB3*LMOD2*MAP3K8*MEF2C*MIB1*MYH6*MYLK2*MYOM1*NEBL*
NEXN*NKX2-6*NNT*NONO*NOS1AP*NOTCH1*NPPA*NRAP*OBSCN*OPA3*
PDHA1*PDLIM3*PERP*PHKA1*PITX2*PKD2*PKP4*PPP1CB*PPP1R13L*PSEN1*
PSEN2*RANGRF*RASA1*RASA2*RBM24*RRAS*SCN10A*SCN3B*SCN4B*SGCA*
SGCB*SLC25A4*SLMAP*SOS2*SPRED1*SPRY1*SYNE1*SYNE2*SYNGAP1*TGFB3*
TMEM175*TMOD1*TOR1AIP1*TRIM54*TSFM*TXNRD2*VCL*WISP1*WT1*XK*
ZFHX3*
Arrhythmias and Sudden Death global panel [251 genes]

It includes priority genes with a clear association with these diseases, secondary genes where the evidence is lower, and candidate genes gathered from a systematic literature review.

Study requisition form
Informed consent
ACTC1BAG3CACNA1CCALM1
CALM2CALM3CASQ2DES
DMDDSC2DSG2DSP
EMDFHL1FHOD3FLNC
GLAJUPKCNE1KCNE2
KCNH2KCNJ2KCNQ1LAMP2
LMNAMYBPC3MYH7MYL2
MYL3NKX2-5PKP2PLN
PRKAG2PTPN11RBM20RYR2
SCN5ATNNC1TNNI3TNNT2
TPM1TRIM63TTNTTR
AARS2ACAD9ACADVLACTA1
ACTN2AGKAGLAGPAT2
AKAP9ALMS1ALPK3ANK2
ANO5ATPAF2CACNA1DCACNA2D1
CACNB2CAV3COA5COA6
COQ2COX15COX6B1CRYAB
CSRP3CTNNA3DLDDNAJC19
DOLKDTNAEYA4FAH
FHL2FKRPFKTNFOXRED1
GAAGATA4GATA5GATA6
GFM1GJA5GLB1GNB2
GNPTABGUSBGYG1HCN4
HFEHRASIRX3JPH2
KCND3KCNE3KCNE5KCNJ5
KCNJ8KLHL24KRASLAMA2
LDLRLIASLZTR1MAP2K1
MAP2K2MLYCDMRPL3MRPL44
MRPS22MTO1MYBPHLMYOT
MYOZ2MYPNNF1NRAS
PMM2PPA2PPCSPRDM16
QRSL1RAF1RIT1SCN1B
SCN2BSCO2SDHASGCD
SGCGSHOC2SLC22A5SLC25A3
SNTA1SOS1SPEGSURF1
TAZTBX20TBX5TCAP
TECRLTMEM43TMEM70TNNI3K
TRDNTRPM4ZBTB17A2ML1*
ABCC9*AKT1*ANK3*ANKRD1*
ATP5F1E*BRAF*BSCL2*C10orf71*
CALR*CALR3*CASZ1*CAVIN1*
CAVIN4*CBL*CDH2*CHRM2*
COL7A1*CTNNA1*CTNNB1*DNM1L*
ELAC2*FBXO32*FGF12*FXN*
GATAD1*GJA1*GPD1L*GREM2*
GSK3B*IDH2*ILK*ISM2*
JARID2*KAT6B*KCNA5*KCND2*
KCNK17*KLF10*LAMA4*LDB3*
LMOD2*MAP3K8*MEF2C*MIB1*
MYH6*MYLK2*MYOM1*NEBL*
NEXN*NKX2-6*NNT*NONO*
NOS1AP*NOTCH1*NPPA*NRAP*
OBSCN*OPA3*PDHA1*PDLIM3*
PERP*PHKA1*PITX2*PKD2*
PKP4*PPP1CB*PPP1R13L*PSEN1*
PSEN2*RANGRF*RASA1*RASA2*
RBM24*RRAS*SCN10A*SCN3B*
SCN4B*SGCA*SGCB*SLC25A4*
SLMAP*SOS2*SPRED1*SPRY1*
SYNE1*SYNE2*SYNGAP1*TGFB3*
TMEM175*TMOD1*TOR1AIP1*TRIM54*
TSFM*TXNRD2*VCL*WISP1*
WT1*XK*ZFHX3*
Nota genes
NOTES ON GENES
-> Priority genes: Genes where there is sufficient evidence (clinical and functional) to consider them as associated with the disease; they are included in clinical practice guidelines. -> Secondary genes: Genes related to the disease but with a lower level of evidence
or constituting sporadic cases. -> * Candidate genes: Without sufficient evidence in humans but potentially associated with the disease.

It includes all diseases that can produce arrhythmias (high predisposition to sudden death), either with or without the presence of structural heart disease. As such, it includes all cardiomyopathies, channelopathies, and cardiac conduction diseases.

  • This panel is mainly aimed at the diagnosis of cases where it is not possible to establish a clearly defined phenotype, but where cardiac arrhythmias are the main manifestation.
  • It is mainly intended for subjects with personal or familial history of sudden death with unknown origin or subjects with ventricular fibrillation of unknown origin that meet the above-mentioned characteristics.

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